Table of Contents
Are imines Schiff bases?
Schiff bases are the compounds carrying imine or azomethine (–C=N–) functional group and are found to be a versatile pharmacophore for design and development of various bioactive lead compounds.
What is Schiff base structure?
A Schiff base (named after Hugo Schiff) is a compound with the general structure R1R2C=NR’ (R’ ≠ H). The term Schiff base is normally applied to these compounds when they are being used as ligands to form coordination complexes with metal ions.
Which can form Schiff base?
Schiff’s bases are formed when any primary amine reacts with an aldehyde or a ketone under specific conditions. In other words, it is a nitrogen analogue of a ketone or aldehyde where the carbonyl group has been replaced by azomethine or imine group.
What is Schiff’s base How is it formed?
Schiff base refers to the imine bonds formed by nucleophilic attack of amine to aldehyde groups, which have been recently used as dynamic covalent bonds for fabricating self-healing hydrogels as shown in Fig. 10.20.
Why are Schiff bases important?
Schiff bases are active against a wide range of organisms since they play an important role in living organisms, such as decarboxylation, transamination and C-C bond cleavage. Decarboxylation and transamination are of importance in the biosynthesis of hormones, neurotransmitters and pigments.
How does LiAlH4 reduce?
LiAlH4 is a strong, unselective reducing agent for polar double bonds, most easily thought of as a source of H-. It will reduce aldehydes, ketones, esters, carboxylic acid chlorides, carboxylic acids and even carboxylate salts to alcohols. Amides and nitriles are reduced to amines.
What does LiAlH4 do to nitriles?
Nitriles can be converted to 1° amines by reaction with LiAlH4. During this reaction the hydride nucleophile attacks the electrophilic carbon in the nitrile to form an imine anion.