Table of Contents
What does renal fibrosis mean?
Renal fibrosis is the consequence of excessive accumulation of extracellular matrix and represents a failed wound-healing process of the kidney tissue.
What is renal proximal tubule cell?
The proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located.
What role does the proximal tubule play in renal excretion?
The proximal tubule, especially the distal straight portion, is responsible for the elimination of urea, excess metabolites, and toxic substances. Urea is filtered in the glomerulus and half of that is reabsorbed by the epithelial cells of the proximal tubule.
What causes fibrosis of the kidney?
Renal fibrosis, particularly associated with glomerulosclerosis and renal interstitial fibrosis (5,10,27,28) that is characterised by tubular atrophy, tubular dilatation, increased fibrogenesis (29) and deposition of collagen and ECM (15), can progress in humans as a consequence of chronic infection, obstruction of the …
How is renal fibrosis treated?
There are currently no drugs for CKD and fibrosis in clinical use that would specifically target the kidney. Despite a number of potential anti-fibrotic treatment targets identified in preclinical studies, translation to clinical trials has remained remarkably poor.
Why is fibrosis bad for kidney?
A final, common pathway in chronic kidney disease is fibrosis, the formation of internal scar tissue, which can cause devastating effects. In the kidneys, it can ultimately lead to end-stage kidney failure. Recent research has shown that after acute kidney injury, the kidneys often fail to repair themselves completely.
What is the main function of the proximal tubule?
The proximal tubule contributes to fluid, electrolyte, and nutrient homeostasis by reabsorbing approximately 60%–70% of the water and NaCl, a greater proportion of the NaHCO3, and nearly all of the nutrients in the ultrafiltrate.
What is the main function of the proximal convoluted tubule?
The function of the PCT is to reabsorb most of the filtered Na+ ions in order to deliver only a small quantity of Na+ ions to downstream sites; these latter sites can then adjust their rate of reabsorption of Na+ ions to achieve balance for this cation in the steady state.
What is the main function of renal tubule?
The major function of tubules is reabsorption and the process can either be through active transport or passive transport. In addition, secretions by tubules help in the urine formation without affecting the electrolyte balance of the body.
What is the best description of polycystic kidney disease?
Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large.