Table of Contents
What are bilayer tablets give examples?
Table: 2 Some examples for combination of drug used as bilayer tablets. Metformin hydrochloride + Pioglitazone Reduce frequency of administration and improve patient compliance ( Ramesh et al., 2010). Diltiazem hydrochloride + Lovastatin Improve patient compliance and better disease management ( Kulkarni et al., 2008).
Why bilayer tablet formulation?
Such a tablet has a fast releasing layer and may contain bi- or triple layers to sustain the drug release. Bilayer tablets present a better choice where one layer provide immediate dose which is then maintains the plasma drug level by its controlled release layer of the tablet.
How do you make a bilayer tablet?
Bilayer tablets are prepared with one layer of the drug for immediate release with the second layer designed to release the drug later, either as a second dose or in an extended-release form.
What is a bilayer tablet?
Bilayer tablets are the medicines which consist of two same or different drugs combined in a single dose for effective treatment of the disease.
What are the types of tablets?
Types of tablets
- a. Compressed tablets.
- b. Sugar-coated Tablets.
- c. Film-Coated Tablets.
- d. Effervescent Tablets.
- e. Enteric-coated Tablets.
- f. Chewable Tablets.
- g. Buccal and Sublingual Tablets.
What is the advantage of using a bilayered tablet?
Bilayer tablets offer other advantages like: prolonging the patent life of a drug product (4), increased efficacy of the active components due to their additive or synergistic effect (5), reduced toxicity (6), improved adherence to treatment regimens by patients (7), convenience of use (1), and facilitating the …
What is an advantage of using bilayer tablet?
What is sustained release tablet?
Sustained-release tablets are manufactured to be more potent but dissolve slowly so they release small amounts of a medication into a patient’s system over an extended period of time. Controlled release technologies allow patients and physicians to be in better control of patient health.
What is the benefit of Bilayered tablets?
What are examples of capsules?
Selecting a capsule type
- Hard gelatin capsules.
- HPMC capsules.
- Fish gelatin capsules.
- Starch capsules.
- Pullulan capsules.
- Polyvinl acetate (PVA) capsules.
- Liquid-filled hard capsules (LFHC).
- Soft gelatin capsules (SGC).
What is compression coating?
Compression-coated formulations can be used to protect hygroscopic, light-sensitive, oxygen- or acid-labile drugs, or to separate incompatible drugs from each other. They can also be used to achieve controlled release, and a number of studies (2) have evaluated compression-coated time-controlled drug delivery systems.
How many MG is in a bilayer tablet?
In the preparation of bilayer tablet, fraction of the drug in both the phase was adjusted as per USP requirement for initial drug release of 50–60%. Hence the present formulations contain total dose of 87.5 mg which includes 37.5 mg as a loading dose in immediate release layer and 50 mg is a maintenance dose in sustained release layer.
What kind of polymers are used in bilayer tablet?
The type of polymers used in combination with FNM (X1) and percent polymer replaced with FNM (X2) were taken as independent formulations variables.
Which is the best route of bilayer tablet administration?
Mahesh, K (2011) Formulation and Evaluation of Bilayer Tablet Containg Pseudoephedrine HCL SR and Loratadine Ir. Masters thesis, K K College of Pharmacy, Chennai, Tamil Nadu, India. The oral route of drug administration is the most important method of administering drug for systemic effect.
Why does bilayer tablet have a short duration of action?
Upon administration of the dosage form the therapeutic plasma concentration is reached very quickly but does not maintain the drug level in the blood for an extended period of time. They have a very short duration of action. The short duration of action is due to inability of conventional dosage form to control temporal delivery.