Table of Contents
What class of medication is donepezil hydrochloride?
Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain.
What are the contraindications of donepezil?
Who should not take DONEPEZIL HCL?
- neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion.
- atrioventricular block, a type of slow heart rhythm disorder.
- sick sinus syndrome.
- sinus bradycardia.
- asthma.
- stomach or intestinal ulcer.
- bleeding of the stomach or intestines.
How is donepezil metabolized?
Donepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified. Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 and undergoes glucuronidation.
What is the indication for donepezil?
INDICATIONS AND USAGE ARICEPT is indicated for the treatment of dementia of the Alzheimer’s type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer’s disease.
Can donepezil make memory worse?
Conclusion: There were no changes in global cognitive performance or dementia severity; however, a subgroup of patients with FTD can experience worsening of symptoms with donepezil.
What medications should not be taken with donepezil?
Drug Interactions
- Bepridil.
- Cisapride.
- Fluconazole.
- Mesoridazine.
- Pimozide.
- Terfenadine.
- Thioridazine.
What are the side effects of donepezil?
Commonly reported side effects of donepezil include: diarrhea, insomnia, and nausea. Other side effects include: fatigue, muscle cramps, vomiting, weight loss, anorexia, and ecchymoses.
Does donepezil cause weight loss?
Aricept (donepezil) can cause weight loss, especially if you’re taking higher doses. If this bothers you, talk to your doctor.
Why is donepezil prescribed?
Donepezil is used for the treatment of symptoms caused by Alzheimer’s dementia. While the medicine does not cure or slow the progression of the disease, it can be used to help improve memory, attention, reason, language, and the ability to perform simple daily tasks.
What is donepezil HCl used for treating?
Donepezil HCl. Sold under the brand name Aricept ®, donepezil hydrochloride (HCl) is a prescription medication used to treat the symptoms of mild, moderate, or severe Alzheimer’s disease.