Table of Contents
What causes punctate Keratoderma?
In most families, punctate palmoplantar keratoderma type 1 is caused by a mutation in the AAGAB gene . The gene is thought to play an important role in skin integrity. When the gene is not working properly, the skin clumps together, forming the bumps on the skin that are characteristic of the condition.
What is punctate Keratoderma?
Punctate palmoplantar keratoderma (punctate PPK), or keratosis punctata, is a heterogeneous group of conditions characterized by small hyperkeratotic growths on the palms and soles. Many cases are inherited in an autosomal dominant fashion, although sporadic cases have also been reported. There is no sex predilection.
How do you treat Palmoplantar Keratoderma?
Treatment
- Saltwater soaks.
- Emollients.
- Paring (cutting away layers of skin)
- Topical keratolytics (useful for people with limited keratoderma)
- Topical retinoids (this is often limited by skin irritation)
- Systemic retinoids (acitretin)
- Topical vitamin D ointment (calcipotriol)
Is there a cure for Keratoderma?
Inherited palmoplantar keratodermas are not curable but symptoms can be controlled. The aim of treatment is to reduce the thickness of the skin and to soften the skin.
What causes thickening of the skin on hands and feet?
Hyperkeratosis is a thickening of the outer layer of the skin. This outer layer contains a tough, protective protein called keratin. This skin thickening is often part of the skin’s normal protection against rubbing, pressure and other forms of local irritation. It causes calluses and corns on hands and feet.
Is Palmoplantar Keratoderma curable?
How is palmoplantar keratoderma treated? Inherited palmoplantar keratodermas are not curable but symptoms can be controlled. The aim of treatment is to reduce the thickness of the skin and to soften the skin.
What kind of skin condition is punctate palmoplantar keratoderma?
Punctate palmoplantar keratoderma type I is a rare condition that affects the skin. It is a sub-type of punctate palmoplantar keratoderma.
What does keratoderma stand for in medical terms?
‘ Keratoderma ’ is a term that means marked thickening of the skin. ‘Palmoplantar’ refers to the skin on the soles of the feet and palms of the hands; these are the areas keratoderma affects most often. Palmoplantar keratoderma is also sometimes known as ‘keratosis palmaris et plantaris’. Classification…
What’s the difference between tripe palms and keratoderma?
Tripe palms – the appearance differs to that of keratoderma with thickened velvety palms that have the appearance of tripe. It is often associated with acanthosis nigricans (AN). Approximately 90% of cases of tripe palms are associated with internal malignancy. The cutaneous features usually pre-date the diagnosis of the cancer.
What kind of hyperkeratosis does Vorner keratoderma cause?
Vorner (epidermolytic) PPK and Unna-Thost (nonepidermolytic) PPK are the result of keratin mutations and show waxy or verrucous, white-yellow, symmetric hyperkeratosis. Mal de Meleda is a rare diffuse hereditary PPK associated with SLURP1 mutations and features stocking-glove distribution of hyperkeratosis with malodor and nail changes.