Table of Contents
Is prothrombin gene mutation dominant or recessive?
Prothrombin-related thrombophilia is inherited in an autosomal dominant pattern. All individuals inherit two copies of each gene .
How common is prothrombin gene mutation?
A change in the prothrombin gene is present in 2-4% (or 1 in 50 to 1 in 25) of Caucasians, and is more common in individuals of European ancestry. In the United States, approximately 0.4% (about 1 in 250) of African Americans also have the mutation. Prothrombin G20210A mutation is rare in other groups.
How is prothrombin gene mutation treated?
No treatment can prevent the prothrombin gene mutation or make it go away. The goal of treatment is to prevent blood clots (see next question and page 7). If you have had a blood clot, you may be treated with medications called anticoagulants. Anticoagulants are used to help to prevent blood clots.
How is prothrombin gene mutation inherited?
The Prothrombin Gene Mutation is an inherited condition (i.e. from your parents). We inherited one copy of each gene from each of our parents. One (or both) of your parents will have passed the Prothrombin Gene Mutation on to you and you may pass the condition onto your children.
What causes prothrombin gene mutation?
What Causes a Prothrombin Gene Mutation? Your parents each pass down one copy of their genes to you at birth. Therefore, everyone has two prothrombin genes. A random change, or mutation, in this gene can be inherited from one or both parents.
Can you donate blood with prothrombin gene mutation?
People with factor V Leiden may donate blood, platelets or plasma safely, as long as they are not on an anticoagulant such as warfarin.
Can you have a baby with prothrombin gene mutation?
The second most common genetic type is prothrombin thrombophilia, which mainly affects people of European ancestry. It involves a mutation in the F2 gene. Genetic types of thrombophilia may raise the risk of multiple miscarriages, but most women with these genetic mutations have normal pregnancies.
What is a normal value for a PT INR?
In healthy people an INR of 1.1 or below is considered normal. An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung.
Can you donate blood if you have prothrombin?
Does prothrombin mutation cause clots?
Having the prothrombin mutation increases the risk of developing a DVT (a blood clot in the deep veins, typically the legs) and/or PE (blood clot that travels to the lungs). DVTs are dangerous because they can damage the veins, leading to pain and swelling, and sometimes to disability.
Is the prothrombin gene mutation common in Australia?
The Prothrombin Gene Mutation is relatively common – it occurs in about 1 in every 50 people in Australia. This mutation is more common than many other gene changes (mutations). Because the mutation is very common, it has been suggested that there is some “benefit” in having the Prothrombin Gene Mutation.
How does a mutation in the prothrombin gene affect your health?
Having the Prothrombin Gene Mutation increases your risk of having a blood clot. If you have one copy of the Prothrombin Gene Mutation (also called being a heterozygote for this gene), you are at around 3 times more at risk of developing a blood clot compared to someone your age who does not have this gene change
What is the treatment for the prothrombin 20210 mutation?
What Is the Treatment for the Prothrombin 20210 Mutation? If you have already had a DVT or PE, then you were likely treated with blood thinning medication, also called anticoagulants. Anticoagulants such as warfarin (Coumadin; Bristol-Myers Squibb Company) are given for a variable length of time, depending on your situation.
Can a person have both copies of the prothrombin gene?
It is rare to have a mutation in both copies of the prothrombin gene, ie, have inherited the mutation from both your mother and your father, but if you do, you are said to be homozygous. How Is the Diagnosis Made? The diagnosis of a prothrombin mutation is made by a blood test.