What is the relationship between serum creatinine and GFR?
Serum Creatinine: Creatinine is a waste product in your blood that comes from muscle activity. It is normally removed from your blood by your kidneys, but when kidney function slows down, the creatinine level rises. Your doctor should use the results of your serum creatinine test to calculate your GFR.
Are creatinine and GFR related?
GFR is a routine lab that can be found on your blood work report. GFR is a calculation that includes your creatinine, along with your age, gender, race, and weight. Your GFR number will help your healthcare provider know if you have kidney disease.
Does creatine underestimate GFR?
When the GFR is low, the serum creatinine and creatinine clearance overestimate the true GFR. Some drugs (such as cimetidine or trimethoprim) have the effect of reducing tubular secretion of creatinine. This increases the serum creatinine and decreases the measured creatinine clearance (Table 3).
Can GFR be low with normal creatinine?
People over age 60 may have an apparently normal creatinine blood level but still have a low GFR and creatinine clearance. The 24-hour urine collection method, or one of the GFR estimation formulas, can more accurately identify the decline in kidney function.
Should I worry if my GFR is 46?
A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.
How to calculate GFR for serum creatinine level?
GFR = 175 × (S Cr) -1.154 × (age) -0.203 × (0.742 if female) × (1.212 if Black) where S Cr = serum creatinine in mg/dL
How is the glomerular filtration rate ( GFR ) calculated?
GFR Calculator. The GFR (glomerular filtration rate) Calculator estimates GFR values based on factors including serum creatinine value, age, race, and gender. For comparison purposes, the results for three prevalent formulas used for estimating GFR are provided. This calculator is for people aged 18 years or older.
How is renal function determined by serum creatinine?
This means that the same serum creatinine values can signify different levels of renal function for different people based on muscle mass. Furthermore, creatinine is actively secreted in small amounts in the body resulting in GFR determined through creatinine clearance typically being overestimated by 10-20%.
How to calculate GFR for the MDRD Study?
The IDMS-traceable MDRD study equation. GFR = 175 × (S Cr) -1.154 × (age) -0.203 × (0.742 if female) × (1.212 if Black) where S Cr = serum creatinine in mg/dL.