What is the macrophage in spleen called?
Spleen autofluorescent cells are macrophages and represent the red pulp macrophages of the spleen. Flow cytometry stainings on monocytes in the spleen, blood monocytes, spleen autofluorescent cells, M-CSF, and GM-CSF cultured monocyte-derived macrophages.
Where are macrophages located in spleen?
The most conspicuous macrophage populations of the spleen are located in the marginal zone. Strategically positioned in the bloodstream and adorned with unique sets of pattern recognition receptors, they play an important role in host defense by bridging the innate and adaptive immune systems.
Does the spleen have a marginal zone?
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)
In which structure of the spleen are macrophage cells found completing phagocytosis?
The splenic cords in the red pulp in the spleen serve as important reservoirs for large quantities of macrophages and other phagocytic white blood cells called monocytes.
What is the other name of macrophages?
Thus, macrophages take different names according to their tissue location, such as osteoclasts (bone), alveolar macrophages (lung), microglial cells (brain), histiocytes (connective tissue), Kupffer cells (liver), Langerhans cells (LC) (skin), etc.
What is the function of macrophages in the spleen?
Splenic MΦs have two main protective activities during blood-borne infections. The first and most well characterized is phagocytosis and elimination of pathogens from circulation. However, beyond the task of eliminating blood-borne pathogens, splenic MΦs can play a prominent role in immune system activation.
What are the two main types of tissue in the spleen?
The spleen is the largest lymphatic organ in the body. Surrounded by a connective tissue capsule, which extends inward to divide the organ into lobules, the spleen consists of two types of tissue called white pulp and red pulp. The white pulp is lymphatic tissue consisting mainly of lymphocytes around arteries.