Table of Contents
Does apomorphine cause vomiting?
Severe nausea and vomiting are commonly induced by apomorphine and can be controlled by pretreatment for a few days with oral or rectal domperidone 20 to 30 mg three times daily.
What drug makes cats vomit?
Xylazine hydrochloride, an α2-adrenergic agonist known for its sedative and analgesic effects, is noted to induce vomiting in cats, particularly when administered via subcutaneous or intramuscular routes; however, the drug’s effects can be reversed effectively with an α-adrenoreceptor antagonist such as yohimbine.
Is apomorphine safe for cats?
Apomorphine is an opioid drug that acts as a potent central dopamine agonist to directly stimulate the CRTZ. Therefore, it is less effective in cats than in dogs.
Why is apomorphine contraindicated in cats?
Apomorphine. Typically not recommended as it is not likely to be effective, due to species differences between dogs and cats. The dog’s chemoreceptor trigger zone (CRTZ) is controlled largely by dopamine receptors, so apomorphine typically induces emesis.
What does apomorphine feel like?
you should know that apomorphine injection may cause dizziness, lightheadedness, nausea, sweating, and fainting when you get up too quickly from a lying or sitting position. This is more common when you first start using apomorphine injection or following an increase in dose.
Can you reverse apomorphine?
Previous data have shown that apomorphine-induced respiratory depression can be reversed by the opiate antagonist, naloxone.
Does dexmedetomidine cause vomiting in cats?
Emesis was induced in 11 of 25 xylazine-treated cats and in 13 of 16 dexmedetomidine-treated cats. Dexmedetomidine was more likely to cause vomiting than xylazine (OR, 5.5; 95% confidence interval, 1.1 to 36).
What can make a cat throw up?
Gastrointestinal Causes of Cat Vomiting
- Dietary indiscretion.
- Foreign bodies.
- Parasites.
- Diet hypersensitivity.
- Inflammatory bowel disease.
- Constipation.
- Cancer.
- Ulceration.
When do you give apomorphine?
Apomorphine injection is used to treat ”off” episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in people with advanced Parkinson’s disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) who are …
How does apomorphine work for dogs and cats?
Overview of Apomorphine for Dogs and Cats Apomorphine, also known as Apokyn®, is a derivative of morphine. Unlike morphine, apomorphine does not alleviate pain. Apomorphine stimulates the dopamine receptors in the specific part of the brain that induces vomiting. This drug is typically only given to dogs.
Why does xylazine trigger vomiting in a cat?
Cats are also unusual in that α2-adrenergic receptors are important in their brainstem areas controlling vomiting: this is why the α2-agonist xylazine reliably triggers vomiting in cats.
Are there any medications that can cause vomiting in cats?
For example see Chiu-Ming Ho et al, 2001; Kolahian, Jarolmasjed, 2010; Kolahian, Jarolmasjed, 2012; there are quite a few others! But it is not just xylazine. Other alpha2-adrenergic agonists are reported to cause vomiting in cats.
How long does it take for vomiting after apomorphine injection?
When given intravenously, vomiting occurs rapidly. After intramuscular injection, vomiting usually occurs within 5 minutes but may be more prolonged. Topical administration of apomorphine to the conjunctival sac of the eye is usually effective but is less reliable than injectable.