What kind of disease is eosinophilic granuloma?
Lichtenstein in 1953 included eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease under the disorder histiocytosis X referring to the proliferation of histiocytes (Langerhans cells) due to an unknown etiology. They are now known as Langerhans cell histiocytosis (LCH).
How to diagnose eosinophilic granuloma in cats?
Diagnosis will typically entail a review of the affected cat’s medical history, a thorough physical exam, and a search of the animal’s skin and hair coat for external parasites. Sometimes a skin biopsy will be required. Also, says Dr. Miller, the cat’s behavioral habits must be considered.
How does overproduction of histiocytes lead to granuloma?
These conditions stem from an overproduction of histiocytes, which are a type of white blood cell. When a person produces too many histiocytes, the cells may start attacking the body’s healthy systems. This can lead to disorders and lesions, such as eosinophilic granuloma. Eosinophilic granuloma is rare.
What does it look like when a granuloma eruption occurs?
According to William H. Miller Jr., VMD, a professor of dermatology at Cornell University’s College of Veterinary Medicine, the eruptions can include “oozing masses, yellowish-pink ulcerations, or big tumor-like bumps,” depending on their specific source.
Are there any Orphan Products for eosinophilic granulomatosis?
Learn more orphan products. FDA-approved indication: Treatment of adult patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA). The prognosis may still depend on the severity of the illness in each person and the specific organ systems that are affected.
What is the treatment for eosinophilic granulomatosis with polyangiitis?
Treatment may involve the use of glucocorticoids (steroids) and/or other immunosuppressive therapies. As of December 2017, mepolizumab (Nucala) became the first therapy approved specifically to treat eosinophilic granulomatosis with polyangiitis.