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Is synovial sarcoma biphasic?
Histologically, synovial sarcoma is characterized by epithelial-like and spindle cell components arranged in a biphasic or monophasic pattern, and a poorly differentiated form of synovial sarcoma has also been described recently [6]. The pathologic features of synovial sarcoma are identical in children and adults.
How do you know if you have synovial sarcoma?
Synovial sarcoma is often first noticed as a painless lump. If it is near a nerve, it might cause pain or numbness as it grows. Imaging: If you have symptoms of synovial sarcoma, your doctor will use scans such as X-ray, ultrasound, CT scan, and MRI to take pictures of the tumor.
Can sarcoma be mistaken for something else?
Sarcomas: possible diagnostic errors Since sarcomas can be mistaken for a benign tumor, a hematoma, an abscess or simply a lump of fat, it may sometimes be diagnosed at a late stage. When there is an evaluation error, a physician may also decide on inappropriate surgery, which may complicate the treatment of the tumor.
How aggressive is synovial sarcoma?
Synovial sarcoma is a rare and aggressive soft tissue sarcoma. In the early stages of the condition, it may cause no noticeable signs or symptoms. However, as the tumor grows larger, affected people may notice a lump or swelling.
Can synovial sarcoma be benign?
The common MRI features of synovial sarcoma in adults have been described [9–11]. In children, synovial sarcoma often shows a deceptively nonaggressive appearance on MRI and may mimic a benign process such as a vascular malformation, benign nerve sheath tumor, or inflammatory arthritis.
Can synovial sarcoma be cured?
Synovial sarcoma can be cured if detected in the early stages. However, this cancer rarely causes any signs and symptoms during early stages. It is an aggressive type of sarcoma that may have already spread in the body by the time it is diagnosed.
What are the chances of getting synovial sarcoma?
It occurs in only 1 to 3 people per million. About 800 new cases of synovial sarcoma are diagnosed in the U.S. each year. Synovial sarcoma is somewhat more common in males. It occurs in about 12 males for every 10 females with the cancer.
Can synovial sarcoma be misdiagnosed?
Often, the small size, well-defined margins, and sometimes homogeneous appearance of synovial sarcoma can lead to misdiagnosis as a benign lesion. Berquist et al found that synovial sarcoma was the malignant soft-tissue sarcoma most frequently misdiagnosed as benign.
What could mistaken for sarcoma?
Atypical fibrous histiocytoma (so-called ‘dermatofibroma with monster cells’) is often mistaken for sarcoma, due to the presence of multifocally scattered large bizarre and often multinucleate cells with atypical hyperchromatic nuclei as well as mitotic figures which may be abnormal.
How serious is synovial sarcoma?
The long-term outlook ( prognosis ) for people with synovial sarcoma depends on many factors, including the size, grade and stage of the tumor ; where the tumor is located; and the affected person’s age and overall health. In general, synovial sarcoma has a survival rate of 50-60% at 5 years and 40-50% at 10 years.
What kind of morphologies are found in synovial sarcoma?
PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuesynovialsarc.html. Accessed July 2nd, 2021. Multiple morphologies, including monophasic spindle cell, biphasic, poorly differentiated, myxoid, ossifying and monophasic epithelial
Is there difference between monophasic and biphasic synovial sarcoma?
No known differences are noted in the clinical behavior of monophasic and biphasic synovial sarcoma; therefore, this distinction is not important for clinical management purposes Surgery with or without adjuvant chemotherapy / radiotherapy is the treatment of choice, if feasible
When does synovial sarcoma fusion of SS18 occur?
E. Synovial sarcoma has fusion of SS18 with SSX1, SSX2 or SSX4. It typically occurs in younger patients, with the peak incidence in the third – fourth decade and most cases show at least focal cytokeratin expression. It is not associated with PAX3 rearrangements, a typical finding in alveolar rhabdomyosarcoma…
How long does it take for synovial sarcoma to grow?
Two features associated with synovial sarcoma that may lead to an initial mistaken diagnosis of a benign indolent process are slow growth (average time to diagnosis, 2–4 years) and small size (< 5 cm at initial presentation); in addition, these lesions may demonstrate well-defined margins and homogeneous appearance on cross-sectional images.