Which drug is contraindicated with theophylline?
Theophylline is contraindicated if the patient previously developed a hypersensitivity reaction to the drug or any component of its formulation (such as an allergy to corn-related products (in injection use only).
Which of the following should be avoided while taking theophylline?
Drinking or eating foods high in caffeine, like coffee, tea, cocoa, and chocolate, may increase the side effects caused by theophylline. Avoid large amounts of these substances while you are taking theophylline.
When should you not use theophylline?
Fever of 102 degrees F or higher for 24 hours or more or. Hypothyroidism (underactive thyroid) or. Infection, severe (e.g., sepsis) or. Kidney disease in infants younger than 3 months of age or.
What are the main drug interactions of theophylline?
TABLE II. Clinically significant drug interactions with theophylline.*
| Drug | Type of Interaction |
|---|---|
| Carbamazepine | Similar to aminoglutethimide. |
| Cimetidine | Decreases theophylline clearance by inhibiting cytochrome P450 1A2. |
| Ciprofloxacin | Similar to cimetidine. |
| Clarithromycin | Similar to erythromycin. |
Why aminophylline is not recommended?
Intravenous aminophylline is not recommended for acute exacerbations. Theophylline is a relatively poor bronchodilator, as adverse effects limit the dose and make it less effective than inhaled bronchodilators.
Is theophylline good for COPD?
Theophylline is a bronchodilator that’s been used in the treatment of COPD for more than seven decades. It is used to treat wheezing or shortness of breath caused by asthma, bronchitis, emphysema and other breathing disorders. It works by relaxing the muscles in the lungs and chest, making it easier to breathe.
Is there a substitute for theophylline?
Abstract: Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of respiratory diseases, but with an improved tolerability profile and a favorable risk-to-benefit ratio.
Is doxofylline better than theophylline?
Another study that enrolled patients suffering from asthma or COPD showed that doxofylline was more effective than theophylline as demonstrated by improvement in pulmonary function tests, as well as clinical symptoms, a reduced incidence of adverse effects and the need for “rescue” bronchodilator use.