Table of Contents
What is the function of ATP dependent chromatin remodeling complexes quizlet?
ATP-dependent chromatin remodeling may effect position of nucleosomes, evict histones, and may replace histones with histone variants. The addition of methyl groups to bases of DNA after DNA synthesis. Inhibits initiation of transcription when occurs near promoter.
What do chromatin remodeling enzymes do?
Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle.
How does chromatin remodeling work?
Chromatin remodeling involves a dynamic interchange between open (transcriptionally active) and closed (transcriptionally repressed or silenced) chromatin structures and is controlled by enzymatic modification of the DNA and/or histone proteins, such as DNA methylation and histone acetylation, respectively.
How does chromatin remodeling affect gene expression?
Chromatin remodeling plays a central role in the regulation of gene expression by providing the transcription machinery with dynamic access to an otherwise tightly packaged genome.
What does ATP dependent mean?
Term: ATP-dependent protein binding. Definition: Binding to a protein or protein complex using energy from ATP hydrolysis.
Which of the following are key differences between eukaryotic and prokaryotic transcriptional regulation quizlet?
Which of the following are key differences between eukaryotic and prokaryotic transcriptional regulation? Combinatorial control of gene expression is more common in eukaryotes. The complexity of eukaryotic development requires that transcription be more coordinated and integrated than in prokaryotes.
At what levels does gene regulation occur in prokaryotes quizlet?
In bacteria, gene expression can be controlled at what three levels? Transcription, translation or post-translation. Negative control occurs when a regulatory protein prevents transcription.
What happens during chromatin remodeling?
Chromatin remodeling is the rearrangement of chromatin from a condensed state to a transcriptionally accessible state, allowing transcription factors or other DNA binding proteins to access DNA and control gene expression.
How does chromatin remodeling regulate gene expression?
How are ATP-dependent chromatin remodeling complexes regulate gene expression?
ATP-dependent chromatin-remodeling complexes regulate gene expression by either moving, ejecting or restructuring nucleosomes.
What is the purpose of chromatin remodeling in DNA?
By definition, chromatin remodeling is the enzyme-assisted process to facilitate access of nucleosomal DNA by remodeling the structure, composition and positioning of nucleosomes. Access to nucleosomal DNA is governed by two major classes of protein complexes:
What kind of diseases are associated with chromatin remodeling?
Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.
Which is permissible for transcription euchromatin or hetero chromatin?
Euchromatin (loose or open chromatin) structure is permissible for transcription whereas heterochromatin (tight or closed chromatin) is more compact and refractory to factors that need to gain access to the DNA template.