How is plasmacytoma diagnosed?
A person is diagnosed with a solitary plasmacytoma when: a biopsy reveals a single tumour inside the bone or tissue comprising abnormal plasma cells; x-rays, positron electron tomography (PET scan) or magnetic resonance imaging (MRI) scans show no other lesions in the bone or in the soft tissues; bone marrow biopsy …
Is solitary plasmacytoma malignant?
Solitary plasmacytoma (SP) is an early-stage plasma cell malignancy that is in between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) along the spectrum of plasma cell disorders.
Is plasmacytoma considered multiple myeloma?
Multiple myeloma is not confined to a specific bone or location within a bone. It tends to involve the entire skeleton. When only one lesion is found it is called a “plasmacytoma.” Most doctors believe that plasmacytoma is simply an early, isolated form of multiple myeloma.
Is plasmacytoma considered cancer?
A type of cancer that begins in plasma cells (white blood cells that produce antibodies). A plasmacytoma may turn into multiple myeloma.
How is plasmacytoma treated?
Treatment of extramedullary plasmacytoma may include the following:
- Radiation therapy to the tumor and nearby lymph nodes.
- Surgery, usually followed by radiation therapy.
- Watchful waiting after initial treatment, followed by radiation therapy, surgery, or chemotherapy if the tumor grows or causes signs or symptoms.
What is the difference between plasmacytoma and myeloma?
Solitary plasmacytoma is a rare disorder that is similar to multiple myeloma. People with solitary plasmacytoma do not have myeloma cells in the bone marrow or throughout the body. Instead, they have a tumor composed of plasma cells that is restricted to a single area of the body.
Is plasmacytoma curable?
Solitary plasmacytoma of the bone can sometimes be cured with radiation therapy or surgery to destroy or remove the tumor. However, 70 percent of people with solitary plasmacytoma eventually develop multiple myeloma.
What are the diagnostic criteria for solitary bone plasmacytoma?
Diagnostic criteria for solitary bone plasmacytoma has been considered as follows 1: Solitary expansile lytic lesion with thinning and destruction of the cortex, and bubbly/trabeculated appearance. Characteristically, the absence of sclerotic reaction is seen.
Is there such a thing as solitary plasmacytoma?
Conversely, solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells, with no or minimal BM plasmacytosis and with no other symptoms than those derived from the primary lesion. It can present either as extramedullary (extraosseous) plasmacytoma (EMP), i.e., in soft tissues, or as solitary bone plasmacytoma (SBP).
Can a bone marrow aspiration detect solitary plasmacytoma?
Solitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease.
What are the Diagnostic and treatment criteria for solitary myeloma?
Here, we provide a consensus statement on the diagnostic criteria, prognostic factors, treatment, and response criteria for SP. Readers should be aware that the management of patients with localized or solitary plasmacytomas is different from patients with soft-tissue plasmacytomas in the context of overt multiple myeloma.