For which purpose is desirudin indicated?
Desirudin is used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery. Desirudin is for use after hip replacement surgery.
How is desirudin administered?
Desirudin is administered subcutaneously for preventing venous thromboembolism postoperatively in patients undergoing elective hip replacement surgery. Dosage is subcutaneous injection 15 mg twice daily. After subcutaneous administration, maximum plasma level is reached after 1–3 h.
What is Iprivask?
Iprivask® (desirudin for injection) is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis.
Is desirudin available in the US?
Desirudin (Iprivask®, Canyon Pharmaceuticals™) is a recombinant hirudin derivative that directly inhibits free and fibrin-bound thrombin. Desirudin was the first DTI approved for deep vein thrombosis (DVT) prophylaxis in Europe (Revasc®) and is the newest injectable DTI commercially available in the USA.
What is bivalirudin used for?
Bivalirudin is a medication used to manage and treat patients undergoing percutaneous coronary intervention for acute myocardial infarction.
What are the side effects of argatroban?
Common side effects of Argatroban injection include:
- stomach pain,
- back pain, or.
- minor bleeding or irritation at the injection site.
Is Lepirudin an anticoagulant?
Conclusion: Lepirudin is a safe and effective anticoagulant for patients with HAAbs. The platelet counts of all patients with heparin-induced thrombocytopenia were normalized while they received lepirudin. Careful monitoring of the aPTT and avoidance of trauma while patients are receiving lepirudin are recommended.
How is argatroban given?
Argatroban is given intravenously and drug plasma concentrations reach steady state in 1–3 hours. Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction.
What is the side effect of argatroban?
nausea, vomiting, diarrhea; low blood pressure; shortness of breath; headache, back pain; or.
Is bivalirudin approved for hit?
The DTI bivalirudin is approved for use in patients who are undergoing percutaneous coronary intervention (PCI) and have, or are at risk for, HIT or HIT with thrombosis (HITT).
How is bivalirudin given?
Bivalirudin is given as an infusion into a vein. A healthcare provider will give you this injection during your angioplasty procedure. Your doctor may want you to continue receiving bivalirudin for a few hours after your angioplasty procedure. Bivalirudin can make it easier for you to bleed, even from a minor injury.