Table of Contents
Who makes dexrazoxane?
Cumberland Pharmaceuticals relaunched Totect in late-July 2017. Fosun Pharma has dexrazoxane available.
When do you take dexrazoxane?
The indication for treatment with dexrazoxane is prevention of chronic cumulative cardiotoxicity caused by doxorubicin or epirubicin use in advanced and/or metastatic adult breast cancer patients who have received a prior cumulative dose of 300 mg/m2 of doxorubicin or 540 mg/m2 of epirubicin and when further …
What is the half life of dexrazoxane?
In humans, the terminal half-life of doxorubicin is up to 48 hours and that for dexrazoxane is approximately 2 hours. In humans, free doxorubicin has a distributive half-life of about 5 minutes and a terminal half-life of 20–48 hours, indicating fast uptake into tissues and slow elimination thereafter [18].
Is dexrazoxane FDA approved?
On September 6, 2007, the U.S. Food and Drug Administration approved Totect 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy.
What is the antidote for anthracycline extravasation?
Preclinical and clinical studies are leading to the clinical implementation of dexrazoxane as the first and only proven antidote in anthracycline extravasation. In two multicenter studies dexrazoxane has proven to be highly effective in preventing skin necrosis and ulceration.
Why is dexrazoxane given?
Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications. The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun).
What is dexrazoxane used for?
Is dexrazoxane a chemo?
Dexrazoxane is used to reduce the incidence and severity of heart problems associated with the chemotherapy agent doxorubicin in women being treated for metastatic breast cancer. It is only used for women who have received a high cumulative dose of doxorubicin and who would benefit from continued therapy.
What is the PK a of dexrazoxane?
Dexrazoxane is a whitish crystalline powder that melts at 191° to 197°C. It is sparingly soluble in water and 0.1 N HCl, slightly soluble in ethanol and methanol, and practically insoluble in nonpolar organic solvents. The pK a is 2.1. Dexrazoxane has an octanol/water partition coefficient of 0.025 and degrades rapidly above a pH of 7.0.
How does dexrazoxane work as a chelating agent?
Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane is converted intracellularly to a ring-opened chelating agent that interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline induced cardiomyopathy.
How many milligrams of dexrazoxane to infuse?
Dexrazoxane has been administered as a 15 minute infusion over a dose range of 60 to 900 mg/m2with 60 mg/m2of doxorubicin, and at a fixed dose of 500 mg/m2with 50 mg/m2doxorubicin.
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