Which PPI safe with Plavix?
PPIs known to strongly or moderately reduce Plavix effectiveness should be avoided. Omeprazole is one of these. If a PPI must be used in a patient taking Plavix, consider a PPI that does not interact as strongly. Pantoprazole is one of these.
Does clopidogrel interact with PPI?
Proton pump inhibitors (PPIs) are often used with clopidogrel to prevent gastrointestinal bleeding, however, some evidence suggests that PPIs may interfere with the activation of clopidogrel and diminish its antiplatelet effect.
What happens when clopidogrel is given with a PPI?
Proton pump inhibitors are inhibitors of CYP2C19 with varying degrees of potency. Therefore, PPIs may inhibit activation of clopidogrel to its active metabolite via CYP2C19 leading to decreased serum concentrations of the active metabolite and potentially reducing the antiplatelet effect of clopidogrel.
Is there an interaction between clopidogrel and omeprazole?
FDA is recommending that the co-administration of clopidogrel (Plavix), a drug used to prevent blood clot formation, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid, be avoided because omeprazole reduces the effectiveness of clopidogrel.
What can you not take with Plavix?
FDA Warns Plavix Patients of Drug Interactions
- Tagamet (generic name: cimetidine)
- Prozac, Sarafem, and Symbyax (generic name: fluoxetine)
- Luvox (generic name: fluvoxamine)
- Ticlid (generic name: ticlopidine)
- Diflucan (generic name: fluconazole)
- Nizoral (generic name: ketoconazole)
- VFEND (generic name: voriconazole)
Is it OK to take lansoprazole with clopidogrel?
lansoprazole clopidogrel Combining these medications may reduce the effectiveness of clopidogrel in preventing heart attack or stroke. The interaction is most likely to occur if you are using a higher dosage of lansoprazole than recommended or if you are using it too frequently.
Which proton pump inhibitor should be avoided in a patient taking clopidogrel?
On the other hand, the United States Food and Drug Administration and the European Medicines Agency revised the labelling of clopidogrel, which now mentions that omeprazole and esomeprazole should be avoided in patients treated with clopidogrel, that other acid-lowering agents with minimal or no inhibitory effects on …
What foods should I avoid while taking clopidogrel?
Is there any food or drink I need to avoid? Do not drink grapefruit juice while taking clopidogrel. Grapefruit juice decreases the effects of your medicine, so that it may not work as well to prevent clots.
What is the best antacid to take with clopidogrel?
The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).
What foods should you avoid if you are on clopidogrel?
What happens when a PPI does interact with Plavix?
What happens when a PPI does interact with Plavix? For Plavix (clopidogrel) to work properly in the body, it requires a special protein, or enzyme, called CYP2C19 to help the body digest and use it. PPIs, on the other hand, can stop this enzyme from working.
Is there an interaction between clopidogrel and PPIs?
With this background, the recently postulated drug interaction between proton pump inhibitors (PPIs) and clopidogrel is in a league of its own, spawning a flurry of research and editorializing in a relatively short time, and more is on the way.
What happens if you take clopidogrel with a proton pump inhibitor?
CONCLUSION — Concurrent use of clopidogrel and a proton pump inhibitor (PPI) may result in decreased levels of the clopidogrel active metabolite, and possibly its antiplatelet activity, but whether it results in clinically significant adverse cardiovascular outcomes is not clear.
How are PPIs used to treat GI bleeding?
Accordingly, PPIs are commonly prescribed in patients treated with clopidogrel to reduce the risk of GI bleeding[11,12]. Even though the administration of PPIs in patients treated with clopidogrel reduces the risk for GI bleeding, some pharmacodynamic studies suggested that the antiplatelet effect of clopidogrel is also attenuated by PPIs[13-15].