What are hematopoietic growth factors used for?
Hematopoietic growth factors are a family of regulatory molecules that play important roles in the growth, survival, and differentiation of blood progenitor cells, as well as in the functional activation of mature cells.
Which of the following are hematopoietic growth factors?
They include interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and erythropoietin (EPO).
What are the factors affecting Hemopoiesis?
Cytokines that influence hematopoiesis include those that can be classified into the Common beta chain, Common gamma chain, and IL-6 cytokine families. Growth factors such as EGF, FGF, GDF, IGF, PDGF, and VEGF also affect hematopoietic stem cell differentiation.
What are the factors affecting hematopoiesis?
Which factor is responsible for normal hematopoiesis?
Hematopoietic growth factors can be classified into two groups: those responsible for the regulation of myeloid and erythroid growth and differentiation, called colony-stimulating factors (CSFs), and those concerned with immunity, called lymphokines. Once sequenced, lymphokines are assigned interleukin (IL) numbers.
Is Filgrastim a myeloid growth factor?
Prophylactic use of myeloid growth factors (mainly the colony-stimulating factors filgrastim and pegfilgrastim) in patients of heightened risk can reduce the severity and duration of febrile neutropenia.
What do growth factors stimulate?
Growth factor, any of a group of proteins that stimulate the growth of specific tissues. Growth factors play an important role in promoting cellular differentiation and cell division, and they occur in a wide range of organisms, including insects, amphibians, humans, and plants.
What are the growth factors in erythropoiesis?
The major growth factors regulating in vivo erythropoiesis are granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin- (IL-) 3, stem cell factor (SCF), IL-1, IL-6, IL-4, IL-9, IL-11, insulin growth factor-1 (IGF-1), and erythropoietin (EPO) [9, 10].
What is the role of erythropoietin in ex vivo?
Erythropoietin (EPO) is a key regulator in most ex vivo protocols along with other growth factors such as SCF, IL-3, IGF-1, and Flt-3. Now transfusable units of blood can be produced by using these protocols with their set of own limitations.
Which is the transcription factor that regulates erythropoiesis?
Description. Erythropoietin is the principal hormone that regulates erythropoiesis and its transcription is mediated by hypoxia inducible factor-1 (HIF-1). Binding of Epo to its receptors (EpoR) stimulates erythroid cell division and proliferation and inhibits erythroid progenitor apoptosis Fisher (2003).
How does erythropoiesis maintain oxygen level in the body?
Erythropoiesis is a complex physiological process to maintain oxygen level in the body through production of red blood cells (Elliott, Pham, & Macdougall, 2008).